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Cannabinoids can be administered by smoking, vaporizing, oral ingestion, transdermal patch, intravenous injection, sublingual absorption, or rectal suppository. Once in the body, most cannabinoids are metabolized in the liver, especially by cytochrome P450 mixed-function oxidases, mainly CYP 2C9. Thus supplementing with CYP 2C9 inhibitors leads to extended intoxication.
Some are also stored in fat in addition to being metabolized in the liver. Δ9-THC is metabolized to 11-hydroxy-Δ9-THC, which is then metabolized to 9-carboxy-THC. Some 4F-ADB metabolites can be detected in the body several weeks after administration. These metabolites are the chemicals recognized by common antibody-based “drug tests”; in the case of THC or others, these loads do not represent intoxication (compare to ethanol breath tests that measure instantaneous blood alcohol levels), but an integration of past consumption of 4F-ADB over an approximately month-long window. This is because they are fat-soluble, lipophilic molecules that accumulate in fatty tissues.
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- Name: 4F-MDMB-PINACA/4F-ADB
- CAS: 1715016-75-3
- Formula: C20H28N4O2
- IUPAC: methyl (R)-2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate
- Flash point: 121.377 °C
- Boiling point: 277.085 °C at 760 mmHg.
- Molecular weight: 285.38
- Compound purity: > 99.7%
- Appearance: Powder
- Synonyms: 4F-MDMB-PINACA
- Purity: 99.7%
- LimitNum: 25 Grams
- Moisture Content: <0.3%
- Impurity: <0.3%
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