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This was briefly mentioned in NPSDiscovery Q1 2022 drug report with samples first collected in November 2021 and March 2022 but now the confirmation reports has been released confirming detection of ADB-5Br-INACA and MDMB-5Br-INACA in the USA.
Uniquely, these compounds do not have a tail chain group.
I originally hypothesized them to be intermediates/precursors that get around bans and lab techs in country finish the job but according to this report they where detected in a blended plant material as opposed to a raw powder and one unpublished study claiming CB receptor activity.
*However, recent in vitro studies have shown ADB-5Br-INACA to exhibit cannabinoid (CB) receptor activity (unpublished data by Deventer MH et al.; Ghent University), but overall potency is expected to be low.*
[https://www.npsdiscovery.org/wp-content/uploads/2022/05/MDMB-5Br-INACA\_051721\_CFSRE-Chemistry\_Report.pdf?mc\_cid=f6d05dfd14&mc\_eid=1a744ed089](https://www.npsdiscovery.org/wp-content/uploads/2022/05/MDMB-5Br-INACA_051721_CFSRE-Chemistry_Report.pdf?mc_cid=f6d05dfd14&mc_eid=1a744ed089)
**MDMB-5Br-INACA**
**Methyl 2-\[(5-bromo-1H-indazole-3-carbonyl)amino\]-3,3-dimethylbutanoate**
**Synonyms: 5Br-MDMB-INACA, MDMB-5-bromo-INACA**
**Source: Indianapolis-Marion County Forensic Services Agency Appearance: Plant-Like Material**
**Date Received: March 11, 2022 Date of Report: May 17, 2022**
*MDMB-5Br-INACA is classified as a synthetic cannabinoid. Little to no information is currently known about the activity, potency, and/or toxicity of MDMB-5Br-INACA. New synthetic cannabinoids continue to emerge among the recreation drug supply internationally, seemingly as replacements after a synthetic cannabinoid class-wide ban implemented by China in July 2021 which included most traditional indole and indazole structural scaffolds.1 Many of these new synthetic cannabinoid analogues are unstudied with pharmacological and human effects undetermined. Currently, MDMB-5BrINACA is not a scheduled substance in the United States.*
[https://www.npsdiscovery.org/wp-content/uploads/2022/05/ADB-5Br-INACA\_051721\_CFSRE-Chemistry\_Report.pdf](https://www.npsdiscovery.org/wp-content/uploads/2022/05/ADB-5Br-INACA_051721_CFSRE-Chemistry_Report.pdf)
**ADB-5Br-INACA**
**5-bromo-N-(1-carbamoyl-2,2-dimethyl-propyl)-1H-indazole-3-carboxamide**
**Synonyms: 5Br-ADB-INACA, ADB-5-bromo-INACA Source: Indianapolis-Marion County Forensic Services Agency Appearance: Plant-Like Material**
**Date Received: November 4, 2021 Date of Report: May 17, 2022**
*ADB-5Br-INACA is classified as a synthetic cannabinoid. Little information is currently known about the activity, potency, and/or toxicity of ADB-5Br-INACA. However, recent in vitro studies have shown ADB-5Br-INACA to exhibit cannabinoid (CB) receptor activity (unpublished data by Deventer MH et al.; Ghent University), but overall potency is expected to be low. New synthetic cannabinoids continue to emerge among the recreation drug supply internationally, seemingly as replacements after a synthetic cannabinoid class-wide ban implemented by China in July 2021 which included most traditional indole and indazole structural scaffolds.1 Many of these new synthetic cannabinoid analogues are unstudied with pharmacological and human effects undetermined. Currently, ADB-5Br-INACA is not a scheduled substance in the United States.*
